MutS homologue 2 (MSH2) is a DNA mismatch repair protein that belongs to the MutS family. MSH2 forms two different heterodimers: MutS alpha (MSH2-MSH6) and MutS beta (MSH2-MSH3), which bind to DNA mismatches thereby initiating DNA repair. Heterozygous mutations in the MSH2 gene are a cause of hereditary nonpolyposis colorectal cancer (HNPCC), forming a specific mispair binding complex with MSH3 and MSH6. MutS alpha may also play a role in DNA homologous recombination repair. MSH2 is found in normal cells. Loss of MSH2 is linked to hereditarynonpolyposis colorectal cancer (HNPCC) and MSI-positive endometrial and ovarian cancers. Immunohistochemical analysis of MSH2 expression has been reported to be a practical and reliable method for the routine detection of the vast majority of MSI-H colorectal adenocarcinomas. (Shipping Cost: €200.00)

Troponin I, Cardiac Muscle (Troponin 1) [EP73]

Troponin is a complex of three regulatory proteins (Troponin I, Troponin T and Troponin C) that is integral to muscle contraction in skeletal and cardiac muscle, but not smooth muscle. There are three tissue-specific subtypes for Troponin I: slow-twitch skeletal muscle isoform troponin I (TNNI1), fast-twitch skeletal muscle isoform troponin I (TNNI2) and cardiac troponin I (TNNI3).

Troponin I, Cardiac Muscle (Troponin 1) [EP73]