The INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing. The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics (medulloblastoma, supratenorial primitive neuroectodermal tumors (sPNETs)) is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1. MRTs also originate from the kidney and soft tissues. (Shipping Cost: €200.00)

Hepatocyte Specific Antigen (Hep Par-1) [EP265]

CPS1 is a mitochondrial enzyme that catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. CPS1 also represents a core mitochondrial nucleoid protein. CPS1 is primarily expressed in hepatocytes in the liver. The antigen for Hep par-1 (Hepatocyte) antibody has been identified as CPS1. This CPS1 antibody shows a similar staining profile to Hep par-1 antibody, which is highly specific and sensitive for hepatocytes and derived tumors with rare positivity in hepatoid adenocarcinomas in GI tract as well as several other types of nonhepatic tumors.

Hepatocyte Specific Antigen (Hep Par-1) [EP265]