Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) is a 452 amino acid enyzme belonging to the isocitrate and isopropylmalate dehydrogenases family and contains two nucleotide binding regions. IDH2 is involved in the reduction of NADP+ to NADPH and maintains mitochondrial glutathione levels. Studies suggest that IDH2 plays a role in intermediary metabolism and energy production. IDH2 also tightly associates with the pyruvate dehydrogenase complex. (Shipping Cost: €200.00)

MDR1/ABCB1/P-Glycoprotein [EP271]

The multidrug resistance protein 1 (MDR-1), also known as P-glycoprotein 1 (PgP), is a conserved plasma membrane protein that functions as an ATP-dependent efflux pump with broad specificity. MDR-1 expression is thought to cause cross-resistance to structurally unrelated anti-cancer drugs, which may decrease intracellular drug concentrations. MDR-1 is typically expressed primarily in regions that act as epithelial barriers or perform excretory function in the liver, kidney, gastrointestinal tract, and the blood-brain barrier. In tumors, MDR-1 is widely expressed in many human cancers, commonly found in colon cancer, renal cancer, hepatocellular carcinoma and hematopoietic malignancies.

MDR1/ABCB1/P-Glycoprotein [EP271]