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Histone H3 K27M Mutant/H3K27M [RM192]

Product group: Primary
Monoclonal/ Polyclonal: Monoclonal
Clone: RM192
Host: Rabbit
Isotype: IgG
Application: ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Application notes: 100-1000
Conjugation Type: Unconjugated
Reactivity: Human, Mouse, Rat
General notes: Localization: nucleus, chromosome.
Buffer: citrate pH6.0, EDTA pH8.0
UNSPSC code: 12352203

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. Histone variant H3.3 is typically enriched in active chromatin. (Shipping Cost: €200.00)

Histone H3 K27M Mutant/H3K27M [RM192]

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. Histone variant H3.3 is typically enriched in active chromatin.