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HCV Core NS4 [5D4/10E7]

Product group: Primary
Monoclonal/ Polyclonal: Monoclonal
Clone: 5D4/10E7
Host: Mouse
Isotype: IgG1
Application: Immunofluorescence (IF), Immunohistochemistry (IHC)
Application notes: Prediluted
Conjugation Type: Unconjugated
Reactivity: Human
General notes: Localization: endoplasmic reticulum; multi-pass membrane protein.
Buffer: citrate pH6.0 or EDTA pH8.0
UNSPSC code: 12352203

The Hep C (Hepatitis C) is a small, enveloped, single-stranded, positive sense RNA virus belonging to the family Flaviviridae. Transmission of the virus occurs when blood from an infected individual enters the body of an uninfected individual. Hep C primarily replicates within hepatocytes in the liver, and circulating Hep C particles bind to receptors on the surface and enter these cells. Hep C replicates quickly, producing approximately one trillion particles each day in infected individuals. Hep C RNA polymerase has no proofreading function, so the virus has an exceptionally high mutation rate which may help it elude the host's immune system. Hep C infection results in chronic infections, liver cirrhosis, and hepatocellular carcinoma in most people. Hep C NS3 (nonstructural protein 3) has both protease and helicase activities and is essential for Hep C replication and proliferation. Hep C NS4 (nonstructural protein 4) augments the proteolytic activity of Hep C NS3 through protein-pro

HCV Core NS4 [5D4/10E7]

The Hep C (Hepatitis C) is a small, enveloped, single-stranded, positive sense RNA virus belonging to the family Flaviviridae. Transmission of the virus occurs when blood from an infected individual enters the body of an uninfected individual. Hep C primarily replicates within hepatocytes in the liver, and circulating Hep C particles bind to receptors on the surface and enter these cells. Hep C replicates quickly, producing approximately one trillion particles each day in infected individuals. Hep C RNA polymerase has no proofreading function, so the virus has an exceptionally high mutation rate which may help it elude the host's immune system. Hep C infection results in chronic infections, liver cirrhosis, and hepatocellular carcinoma in most people. Hep C NS3 (nonstructural protein 3) has both protease and helicase activities and is essential for Hep C replication and proliferation. Hep C NS4 (nonstructural protein 4) augments the proteolytic activity of Hep C NS3 through protein-protein interaction