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EGFR (L858R Mutant Specific) [MD27R]
| Product group: | Primary |
| Monoclonal/ Polyclonal: | Monoclonal |
| Clone: | MD27R |
| Host: | Rabbit |
| Isotype: | IgG |
| Application: | Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) |
| Application notes: | Prediluted |
| Conjugation Type: | Unconjugated |
| Reactivity: | Human |
| General notes: | Localization: membrane. |
| Buffer: | EDTA pH8.0 |
| UNSPSC code: | 12352203 |
Two types of mutations account for approximately 90% of mutated cases: a specific point mutation, L858R, which occurs in exon 21 and short in-frame deletions in exon 19. A common lesion in exon 19 is the deletion of E746-A750, although other variants occur. IHC-based EGFR E746-A750del specific antibody is designed to detect deletion of E746-A750 in exon 19. Deletion in exon 19 is associated with response of non-small cell lung carcinoma (NSCLC) to gefitinib or erlotinib monotherapy. (Shipping Cost: €200.00)
EGFR (L858R Mutant Specific) [MD27R]
Two types of mutations account for approximately 90% of mutated cases: a specific point mutation, L858R, which occurs in exon 21 and short in-frame deletions in exon 19. A common lesion in exon 19 is the deletion of E746-A750, although other variants occur. IHC-based EGFR E746-A750del specific antibody is designed to detect deletion of E746-A750 in exon 19. Deletion in exon 19 is associated with response of non-small cell lung carcinoma (NSCLC) to gefitinib or erlotinib monotherapy.
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