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COX2 [MD144R]
Product group: | Primary |
Monoclonal/ Polyclonal: | Monoclonal |
Clone: | SP21 |
Host: | Rabbit |
Isotype: | IgG |
Application: | Immunohistochemistry (IHC) |
Application notes: | 25-50 |
Conjugation Type: | Unconjugated |
Reactivity: | Human |
General notes: | Localization: cytoplasm, membrane. |
Buffer: | citrate pH6.0 |
UNSPSC code: | 12352203 |
COX-2, also known as prostaglandin-endoperoxidase synthase 2 (PTGS2), is an immediate-early gene that encodes a critical enzyme for the conversion of arachidonic acids to prostaglandins. Functionally, COX-2 exists as a homodimer, consisting of two 70kDa subunits. COX-2 derived prostanoids have been shown to increase resistance to apoptosis, promote angiogenesis, induce metastasis and invasion, and impair immune surveillance. Immunohistochemical expression of COX-2 has been described in multiple tissue types. While COX-2 expression is limited in most normal tissues, it is induced by various stimuli and elevated during inflammatory responses. Reports have associated COX-2 expression with cancers from multiple tissues. Lung, colon, gastric, prostate, and breast carcinomas were described to have elevated levels of COX-2. Further, elevated COX-2 levels has been associated with poor prognosis and decreased survival in patients with breast cancer. (Shipping Cost: €200.00)
COX2 [SP21]
COX-2, also known as prostaglandin-endoperoxidase synthase 2 (PTGS2), is an immediate-early gene that encodes a critical enzyme for the conversion of arachidonic acids to prostaglandins. Functionally, COX-2 exists as a homodimer, consisting of two 70kDa subunits. COX-2 derived prostanoids have been shown to increase resistance to apoptosis, promote angiogenesis, induce metastasis and invasion, and impair immune surveillance. Immunohistochemical expression of COX-2 has been described in multiple tissue types. While COX-2 expression is limited in most normal tissues, it is induced by various stimuli and elevated during inflammatory responses. Reports have associated COX-2 expression with cancers from multiple tissues. Lung, colon, gastric, prostate, and breast carcinomas were described to have elevated levels of COX-2. Further, elevated COX-2 levels has been associated with poor prognosis and decreased survival in patients with breast cancer.
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