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CD45RB [BRA-11G]
| Product group: | Primary |
| Monoclonal/ Polyclonal: | Monoclonal |
| Clone: | BRA-11G the same as BRA-11 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Application: | Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) |
| Application notes: | 50-200 |
| Conjugation Type: | Unconjugated |
| Lightchain type: | Kappa |
| Reactivity: | Human |
| General notes: | Localization: membrane. |
| Buffer: | citrate pH6.0 |
| UNSPSC code: | 12352203 |
CD45, a transmembrane multifunctional glycoprotein, is a member of Type I receptor-linked PTPase family and is expressed as multiple isoforms due to alternative splicing. Expression of these isoforms is highly regulated and shift in this expression determines T-cell activation. CD45RB consists of exon B and is predominantly expressed in naive T-cells secreting IL-2. Its expression is low in primed/memory T cells, cells that express Th2 cytokines such as IL-4 and IL-10 and population of T-cells with regulatory function. Immunotherapy with CD45RB antibody is being widely studied in transplantation and vaccination. CD45 antibodies are commonly used to identify tumors of lymphoid origin. (Shipping Cost: €200.00)
CD45RB [BRA-11G]
CD45, a transmembrane multifunctional glycoprotein, is a member of Type I receptor-linked PTPase family and is expressed as multiple isoforms due to alternative splicing. Expression of these isoforms is highly regulated and shift in this expression determines T-cell activation. CD45RB consists of exon B and is predominantly expressed in naive T-cells secreting IL-2. Its expression is low in primed/memory T cells, cells that express Th2 cytokines such as IL-4 and IL-10 and population of T-cells with regulatory function. Immunotherapy with CD45RB antibody is being widely studied in transplantation and vaccination. CD45 antibodies are commonly used to identify tumors of lymphoid origin.
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