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CD42b [42C01]

Product information References Bioinformatics Documents
Product group: Primary
Monoclonal/ Polyclonal: Monoclonal
Clone: 42C01
Host: Mouse
Isotype: IgG1
Application: ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application notes: 10-50
Conjugation Type: Unconjugated
Reactivity: Human
General notes: Localization: membrane.
Buffer: citrate pH6.0 or EDTA pH8.0
UNSPSC code: 12352203

The CD42b glycoprotein, also known as GPIb, is a co-factor of ristocetin-induced aggregation and is involved in the binding of platelets to blood vessel walls. The CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. The absence of CD42b antigen on platelets may indicate Bernard-Soulier disease. CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. Its expression and activation seems to be regulated by VEGF and PDGF. (Shipping Cost: €200.00)

CD42b [42C01]

The CD42b glycoprotein, also known as GPIb, is a co-factor of ristocetin-induced aggregation and is involved in the binding of platelets to blood vessel walls. The CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. The absence of CD42b antigen on platelets may indicate Bernard-Soulier disease. CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. Its expression and activation seems to be regulated by VEGF and PDGF.