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CD38 [AT1]

Product group: Primary
Monoclonal/ Polyclonal: Monoclonal
Clone: AT1
Host: Mouse
Isotype: IgG1
Application: Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application notes: Prediluted
Conjugation Type: Unconjugated
Lightchain type: Kappa
Reactivity: Human
General notes: Localization: membrane.
Buffer: citrate pH6.0 or EDTA pH8.0
UNSPSC code: 12352203

CD38, also called ADP-ribosyl cyclase, is a druggable ectoenzyme that uses nicotinamide adenine dinucleotide (NAD) as a substrate to generate second messengers. In particular, it synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. CD38 also has cADPR hydrolase activity. It is preferentially expressed at both early and late stages of B- and T-cell maturation. In normal lymph nodes and tonsils, the antigen is detected mainly on B cells in germinal centers and plasma cells. An antibody to CD38 is helpful in the identification of plasma cells and tumors with plasmablastic differentiation. A prognostic value of CD38 in B-cell chronic lymphocytic leukemia (CLL) has been reported. Expression of CD38 is linked to unmutated IgVH genes and a worse prognosis. CD38 is involved in the generation of adenosine, which is implicated in tumor immune evasion. CD38 mRNA expression in metastatic castration-resistant prostate cancer (mCRPC) was most significantly associa

CD38 [AT1]

CD38, also called ADP-ribosyl cyclase, is an ectoenzyme that uses nicotinamide adenine dinucleotide (NAD) as a substrate to generate second messengers. In particular, it synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. CD38 also has cADPR hydrolase activity. It is preferentially expressed at both early and late stages of B- and T-cell maturation. CD38 is expressed in a variety of non-hematopoietic and hematopoietic cells, the latter comprising early bone marrow progenitor cells, thymic cells, natural killer cells, activated T cells, and B cells at early and late stages of differentiation, such as plasma cells. In normal lymph nodes and tonsils, the antigen is detected mainly on B cells in germinal centers and plasma cells. An antibody to CD38 is helpful in the identification of plasma cells and tumors with plasmablastic differentiation. A prognostic value of CD38 in B-cell chronic lymphocytic leukemia (CLL) has been reported. Expression of CD38 is linked to unmutated IgVH genes and a worse prognosis.