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CD35 [E11]

Product information References Bioinformatics Documents
Product group: Primary
Monoclonal/ Polyclonal: Monoclonal
Clone: E11
Host: Mouse
Isotype: IgG1
Application: Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC)
Application notes: 50-200
Conjugation Type: Unconjugated
Lightchain type: Kappa
Reactivity: Human, Baboon, Cynomolgus Monkey, Rhesus Macaque
General notes: Localization: membrane.
Buffer: citrate pH6.0
UNSPSC code: 12352203

CD35, also named as erythrocyte complement receptor 1 (CR1), is a member of the complement activation (RCA) family and is located in the ‘cluster RCA’ region of chromosome 1. CD35 mediates cellular binding to particles and immune complexes that have activated complement. CD35 is present on erythrocytes, various leucocytes and renal glomerular podocytes. In addition, plasma contains a soluble form of CR1 (Scr1). CD35 also can be detected on follicular dendritic cells. It is a marker for the diagnosis of follicular dendritic cell sarcoma. This antibody labels dendritic cells in tonsil and spleen and glomerular podocytes in kidney. Abnormal expression of this protein has been associated with follicular dendritic cell tumor, sarcoidosis, gallbladder carcinomas, mesangiocapillary glomerulonephritis, and systemic lupus erythematosus. (Shipping Cost: €200.00)

CD35 [E11]

CD35, also named as erythrocyte complement receptor 1 (CR1), is a member of the complement activation (RCA) family and is located in the ‘cluster RCA’ region of chromosome 1. CD35 mediates cellular binding to particles and immune complexes that have activated complement. CD35 is present on erythrocytes, various leucocytes and renal glomerular podocytes. In addition, plasma contains a soluble form of CR1 (Scr1). CD35 also can be detected on follicular dendritic cells. It is a marker for the diagnosis of follicular dendritic cell sarcoma. This antibody labels dendritic cells in tonsil and spleen and glomerular podocytes in kidney. Abnormal expression of this protein has been associated with follicular dendritic cell tumor, sarcoidosis, gallbladder carcinomas, mesangiocapillary glomerulonephritis, and systemic lupus erythematosus.