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CD180/RP105 [MHR73-11]
| Product group: | Primary |
| Monoclonal/ Polyclonal: | Monoclonal |
| Clone: | MHR73-11 |
| Host: | Rabbit |
| Isotype: | IgG1 |
| Application: | Flow cytometry (FC), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) |
| Application notes: | 10-100 |
| Conjugation Type: | Unconjugated |
| Lightchain type: | Kappa |
| Reactivity: | Human, Baboon, Cynomolgus, African Green, Rhesus |
| General notes: | Localization: membrane. |
| Buffer: | citrate pH6.0 or EDTA pH8.0 |
| UNSPSC code: | 12352203 |
CD180 or RP105, BGP95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression depends on the coexpression of its helper molecule, MD-1 , and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size. (Shipping Cost: €200.00)
CD180/RP105 [MHR73-11]
CD180 or RP105, BGP95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression depends on the coexpression of its helper molecule, MD-1 , and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size.
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