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CD103/Integrin alpha E [ITGAE/2063]
| Product group: | Primary |
| Monoclonal/ Polyclonal: | Monoclonal |
| Clone: | ITGAE/2063 |
| Host: | Mouse |
| Isotype: | IgG2c |
| Application: | Immunohistochemistry (IHC) |
| Application notes: | Prediluted |
| Conjugation Type: | Unconjugated |
| Lightchain type: | Kappa |
| Reactivity: | Human |
| General notes: | Localization: membrane, cytoplasm. |
| Buffer: | citrate pH6.0 |
| UNSPSC code: | 12352203 |
CD103, also known as integrin alpha E (ITGAE), is an integrin protein that in humans is encoded by the ITGAE gene. It binds integrin beta 7 to form the complete heterodimeric molecular αEβ7 that binds to an extracellular matrix component and cellular counter receptor. They mediate cell adhesion, migration and signaling and are important for T lymphocyte localization. CD103 is expressed on intraepithelial lymphocytes in mucosal areas, including lung and GI tract. In malignancies, CD103 is present on all enteropathy-type T-cell lymphomas. Additionally, CD103 has been a useful marker for hairy cell leukemia. (Shipping Cost: €200.00)
CD103/Integrin alpha E [ITGAE/2063]
CD103, also known as integrin alpha E (ITGAE), is an integrin protein that in humans is encoded by the ITGAE gene. It binds integrin beta 7 to form the complete heterodimeric molecular αEβ7 that binds to an extracellular matrix component and cellular counter receptor. They mediate cell adhesion, migration and signaling and are important for T lymphocyte localization. CD103 is expressed on intraepithelial lymphocytes in mucosal areas, including lung and GI tract. In malignancies, CD103 is present on all enteropathy-type T-cell lymphomas. Additionally, CD103 has been a useful marker for hairy cell leukemia.
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